Synthesis of a first thiophene containing analog of the HIV protease inhibitor nelfinavir

A stereoselective and efficient preparation of a thiophene containing intermediate 2 from ethyl 3-thienyl propenoate 4 as the core of new possible HIV protease inhibitors is described. The chiral intermediate has been successfully used for the preparation of the analog 1 of the potent HIV inhibitor nelfinavir.     

Organization of nanoscale objects via polymer demixing

We present an extremely versatile method for the lateral organization of nano-scale objects (NOs) based on the phenomenon of polymer demixing. NOs are suspended in a solution of two immiscible polymers, which is used to form a thin polymer film by spin coating. During spin coating the two polymers separate to give a microphase structure, whose length scale depends on the experimental conditions. The NOs spontaneously partition into one or other of the polymer phases resulting in their lateral organization. In this work, the organization of CdSe nanoparticles and fluorescent organic dyes was studied by fluorescence microscopy. The NOs were organized in the polymer film in stochastic patterns or in ordered designs on substrates pre-patterned by soft-lithography techniques. Single-particle measurements, using confocal microscopy, showed that at low concentrations there was little aggregation of the particles.     

40J激光装置研制

 报道了一台输出能量在40J量级的激光装置。该装置从星光Ⅱ激光装置分光作为光源,由放大器链、能源系统和支撑桁架等三大部分构成。对整个激光装置的模拟计算结果表明：装置的增益能力足够输出40J,B积分满足ΔB小于1.8的要求。研制了一种全腔水冷新型放大器,对其小信号增益系数和增益均匀性进行了测量,实验得出增益系数β为0.034cm ^-1,增益均匀性为91.84%。结果表明这种放大器完全能满足此激光装置的设计要求。     

颜色失真二维彩色条形码的自适应阈值机读法

采用紫外辐照加速老化方法研究纸基彩色条形码的褪色规律。基于CIELAB模型分析紫外辐照累计时间与二维条形码色差的关系，对4色打印标签的检测结果表明：品红色褪变速率较大，青色、黄色和黑色的褪变速率逐次减小。基于RGB三基色直方图和概率统计原理，提出能有效校正颜色失真、正确机读二维条形码的“自适应阈值法”。实验表明：对于紫外25h加速老化后的褪色条形码，“自适应阈值法”的机读误码率≤0.05%。该研究结果为褪色彩色条形码标签进入实用阶段提供了实验依据。     

Simple Analog Complementary Metal Oxide Semiconductor Circuit for Generating Motion Signal

We proposed in this study a novel analog complementary metal oxide semiconductor (CMOS) circuit for generating a motion signal when an object moves, which is a simple structure. The proposed unit circuit was constructed using a previously proposed edge detection circuit and a novel proposed circuit for generating a motion signal which accepts an edge signal. The part for generating the motion signal was constructed using six metal oxide semiconductor (MOS) transistors and one capacitor. Results obtained by the simulation program with integrated circuit emphasis (SPICE) and the measured results of a test circuit constructed with discrete MOS transistors and the test circuit fabricated with a 1.2 μm CMOS process showed that the proposed unit circuit can output pulsed current (motion signal) when an object moves on the circuit. It was clarified from the SPICE results that the two-dimensional network constructed with proposed unit circuits can output motion signals. The size of the novel unit circuit is expected to be about 110 × 110μm² obtained by the 1.2 μm CMOS process. It is possible to arrange 90 × 90 unit circuits on a chip which has an area of 1 × 1cm². The aperture ratio is expected to be about 21%, which is twice as large as that of the previously proposed circuit. An integrated circuit for image processing in real time can thus be realized by applying the two-dimensional network constructed with the proposed circuits.     

High speeds complementary integrated circuits fabricated with all‐printed polymeric semiconductors

Inkjet‐printed high speed polymeric complementary circuits are fabricated using an n‐type ([poly{[N,N′‐bis(2‐octyldodecyl)‐naphthalene‐1,4,5,8‐bis(dicarboximide)‐2,6‐diyl]‐alt‐5,5′‐(2,2′‐dithiophene)} [P(NDI2OD‐T2), Polyera ActivInk N2200] and two p‐type polymers [poly(3‐hexylthiophene) (P3HT) and a dithiophene‐based polymer (Polyera ActivInk P2100)]. The top‐gate/bottom‐contact (TG/BC) organic field‐effect transistors (OFETs) exhibit well‐balanced and very‐high hole and electron mobilities (μ_FET) of 0.2–0.5 cm²/Vs, which were enabled by optimization of the inkjet‐printed active features, small contact resistance both of electron and hole injections, and effective control over gate dielectrics and its orthogonal solvent effect (selection of poly(methyl methacrylate) and 2‐ethoxyethanol). Our first demonstrated inkjet‐printed polymeric complementary devices have been integrated to high‐performance complementary inverters (gain >30) and ring oscillators (oscillation frequency ～50 kHz). We believe that the operating frequency of printable organic circuits can be further improved more than 10 MHz by fine‐tuning of the device architecture and optimization of the p‐ and n‐channel semiconductor processing. © 2010 Wiley Periodicals, Inc. J Polym Sci Part B: Polym Phys, 2010     

Nonlinear analysis of the deformation and breakup of viscous microjets using the method of lines

We present a numerical model for predicting the instability and breakup of viscous microjets of Newtonian fluid. We adopt a one‐dimensional slender‐jet approximation and obtain the equations of motion in the form of a pair of coupled nonlinear partial differential equations (PDEs). We solve these equations using the method of lines, wherein the PDEs are transformed to a system of ordinary differential equations for the nodal values of the jet variables on a uniform staggered grid. We use the model to predict the instability and satellite formation in infinite microthreads of fluid and continuous microjets that emanate from an orifice. For the microthread analysis, we take into account arbitrary initial perturbations of the free‐surface and jet velocity, as well as Marangoni instability that is due to an arbitrary variation in the surface tension. For the continuous nozzle‐driven jet analysis, we take into account arbitrary time‐dependent perturbations of the free‐surface, velocity and/or surface tension as boundary conditions at the nozzle orifice. We validate the model using established computational data, as well as axisymmetric, volume of fluid (VOF) computational fluid dynamic (CFD) simulations. The key advantages of the model are its ease of implementation and speed of computation, which is several orders of magnitude faster than the VOF CFD simulations. The model enables rapid parametric analysis of jet breakup and satellite formation as a function of jet dimensions, modulation parameters, and fluid rheology. Copyright © 2010 John Wiley & Sons, Ltd.     

利用收音机制作激光通信演示器

本文介绍了一种利用学生在电子技术实验课中自己组装的收音机，稍加改造而制作的一种简单适用、并且效果很好的激光通信演示器。     

Estimation of the proton energy spectrum in knee region by analog read-out of ARGO-YBJ experiment

Based on the six months data set of ARGO-YBJ experiment with analog read-out and its Monte Carlo simulation,we study the difference between different primaries induced showers by using the space-time information of the charged particles in Extensive Air Showers.With five parameters which can efficiently pick out primary proton induced showers as inputs of an artificial neural network,the proton spectrum from 100 TeV to 10 PeV can be obtained.